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| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Win | 6-4, 6-2, 6-3 |
| Second Round | Florian Mayer | Win | 7-6 (7-2), 6-4, 7-5 |
| Third Round | Steve Johnson | Win | 6-4, 7-6 (7-3), 6-4 |
| Fourth Round | Roberto Bautista Agut | Win | 6-2, 6-2, 6-2 |
| Quarterfinals | Gilles Muller | Win | 3-6, 7-6 (8-6), 7-5, 5-7, 6-1 |
| Semifinals | Sam Querrey | Win | 6-7 (6-8), 6-4, 7-6 (7-3), 7-5 |
| Final | Roger Federer | Loss | 3-6, 1-6, 4-6 |
| AEGON Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | John Isner | Win | 7-5, 6-3 |
| Second Round | Stefan Kozlov | Win | 6-0, 6-4 |
| Quarterfinals | Donald Young | Win | 6-4, 7-5 |
| Semifinals | Gilles Muller | Win | 6-3, 5-7, 6-4 |
| Final | Feliciano Lopez | Loss | 6-4, 6-7 (2-7), 6-7 (8-10) |
| Ricoh Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Janko Tipsarevic | Win | 6-7 (6-8), 6-2, 6-4 |
| Quarterfinals | Vasek Pospisil | Win | 6-3, 7-5 |
| Semifinals | Ivo Karlovic | Loss | 6-7 (4-7), 7-5, 6-7 (2-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Ernests Gulbis | Win | 6-3, 6-3, 6-3 |
| Second Round | Konstantin Kravchuk | Win | 6-3, 6-2, 6-2 |
| Third Round | Feliciano Lopez | Win | 6-1, 6-3, 6-3 |
| Fourth Round | Kevin Anderson | Win | 6-3, 3-0 Retired |
| Quarterfinals | Stan Wawrinka | Loss | 3-6, 3-6, 1-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ryan Harrison | Win | 6-3, 6-2 |
| Third Round | David Goffin | Win | 6-3, 6-4 |
| Quarterfinals | John Isner | Loss | 6-7 (3-7), 6-2, 6-7 (2-7) |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Zverev | Loss | 7-6 (7-3), 3-6, 4-6 |
| TEB BNP Paribas Istanbul Open | ||
| Surface: Clay | Date: May 1 - May 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Damir Dzumhur | Win | 6-3, 6-2 |
| Quarterfinals | Steve Darcis | Win | 6-1, 6-1 |
| Semifinals | Diego Schwartzman | Win | 6-1, 7-6 (9-7) |
| Final | Milos Raonic | Win | 7-6 (7-3), 6-3 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jeremy Chardy | Win | 6-3, 6-0 |
| Third Round | Tomas Berdych | Win | 6-2, 7-6 (7-0) |
| Quarterfinals | Albert Ramos-Vinolas | Loss | 2-6, 7-6 (7-5), 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jeremy Chardy | Loss | 4-6, 6-2, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Fritz | Loss | 6-4, 5-7, 4-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Alexandr Dolgopolov | Win | 6-3, 4-6, 6-0 |
| Second Round | Borna Coric | Win | 6-3, 2-6, 6-3 |
| Quarterfinals | Steve Johnson | Win | Retired |
| Semifinals | Rafael Nadal | Loss | 1-6, 2-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | 5-7, 6-3, 6-2 |
| Second Round | Borna Coric | Win | 6-1, 2-6, 6-4 |
| Quarterfinals | Jo-Wilfried Tsonga | Loss | 6-7 (8-10), 6-7 (5-7) |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dustin Brown | Loss | 4-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jerzy Janowicz | Win | 4-6, 4-6, 6-2, 6-2, 6-3 |
| Second Round | Daniel Evans | Loss | 6-3, 5-7, 3-6, 3-6 |
| Aircel Chennai Open | ||
| Surface: Hard | Date: Jan. 2 - Jan. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jozef Kovalik | Loss | 6-7 (5-7), 7-5, 5-7 |
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